|
KMID : 0613820060160010136
|
|
Journal of Life Science
2006 Volume.16 No. 1 p.136 ~ p.140
|
|
|
Biotransformation of Ginseng to Compound K by Aspergillus oryzae
|
|
Kim Bo-Hye
Kang Ju-Hyung
Lee Sun-Yi
Cho Hyo-Jin
Kim Young-Jin
Kim Yoon-Jin
Ahn Soon-Cheol
|
|
|
Abstract
|
|
|
|
Ginseng was fermented by Aspergillus oryzae to search metabolites on the basis of increased biological activity and modified structure. From this research, two biotransformed compounds (WG2-2-1 and WG2-2-2) were detected and isolated through several chromatographic techniques. WG2-2-2 was confirmed to biologically active compound K by TLC, HPLC, and mass spectroscopy, while WG2-2-1 was going to be identified until now. In biological activity, both WG2-2-1 and WG2-2-2 exhibit the cytotoxicity on PC-3 cells, but WG2-2-2 was more active than WG2-2-1. It is supposed that WG2-2-1 is an intermediate metabolite transforming to final WG2-2-2, compound K.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|